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Sequencher Publisher Description

Sequencher is the industry standard software for DNA sequence analysis. It works with all automated sequencers and is widely known for its lightning-fast contig assembly, short learning curve, user-friendly editing tools, and superb technical support. First released almost 15 years ago, Sequencher is currently used for sequence analysis tasks in every major genomic and pharmaceutical company as well as numerous academic and government labs in over 40 countries around the world. Life Science researchers use Sequencher for many diverse DNA sequence analysis applications including de novo gene sequencing, mutation detection, forensic human identification, systematics, and more.

Sequencher capabilities include heterozygote & SNP detection and analysis, cDNA to Genomic DNA large gap alignment, comparative sequencing, support for confidence scores, ORF translation, GenBank feature import, and restriction enzyme mapping. Version 4.6, just released, has many new capabilities that can reduce the time required to identify and validate heterozygotes and SNPs in your sequences.
OS: PPC/Intel
Requirements: Mac OS X 10.2 or later.
Whats new:
Version 4.7:

New Controls for Numbering your Reference – Sequencher now lets you define the numbering of your
Reference Sequence so that you can accurately describe positions on both sides of the origin of a circular
sequence.
Sequencher HTML Help – Sequencher 4.7 includes an HTML version of the user manual as well as a context
sensitive, in depth description of Application screens and their functionality.
Updates to the Variance Table – The Variance Table becomes an even more powerful tool for SNP analysis
with additions to “Review Mode”. You can now directly change bases or create features in the Variance Table. As
you do, Sequencher automatically updates the corresponding Contig Editor and Chromatogram windows.
New Editing Functions – Expedite your data editing and better manage gap-ridden sequences using the new
Collect Gaps functionality. Sequencher 4.7 also includes an improved lasso tool and a more accessible ReAligner
function.
Create Project Templates – You can now save, open, or import any project as a Template. Project Templates
allow you to launch Sequencher with your own default parameters and Reference Sequences.
Import of GenBank Files – Sequencher 4.7’s Feature Listing now includes the complete detail of imported
features. New User Preferences let you selectively extract Feature Qualifiers to name your Features in
Sequencher.
New File Formats – Sequencher continues to build on a solid foundation for supporting a vast number of file
formats. This version includes extended support for slightly modified ABI files, as well as the ability to export
and save 4.7 files as earlier Sequencher file formats.
Minor Enhancements and Fixes – A list of refinements for functionality from earlier versions. The
Reference Sequence becomes even more flexible, “Revert to Experimental Data” more intuitive, and a number
of other improvements.
By starting up in demo mode, you can try the new Mitochondrial analysis tools, including the Validate Mitotypes
functionality, available in Sequencher 4.7 Forensic Enabled. If your lab would benefit from the use of these
features, contact your Gene Codes sales representative by phone, fax, or email.

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